منابع مشابه
The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
BACKGROUND The adaptor protein Gads is a Grb2-related protein originally identified on the basis of its interaction with the tyrosine-phosphorylated form of the docking protein Shc. Gads protein expression is restricted to hematopoietic tissues and cell lines. Gads contains a Src homology 2 (SH2) domain, which has previously been shown to have a similar binding specificity to that of Grb2. Gads...
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New developments in lymphocyte signaling have revealed insights into the proximal phosphorylation events associated with the T-cell receptor and into the importance of the T-cell adaptor protein Slp-76 and its B-cell homolog in the transduction of the signal from the antigen receptor.
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Almost all physiological T cell responses require costimulation-engagement of the clonotypic TCR with MHC/Ag and CD28 by its ligands CD80/86. Whether CD28 provides signals that are qualitatively unique or quantitatively amplify TCR signaling is poorly understood. In this study, we use superagonistic CD28 Abs, which induce T cell proliferation without TCR coligation, to determine how CD28 contri...
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The conventional telecommunication software components are mainly developed using message-passing as the underlying communication mechanisms. Recent standards on modern distributed systems, exemplified by CORBA and DCE, however, have converged to a new programming paradigm based on client/server architecture, objectoriented model, and Remote Procedure Calls (RPCs). In the near future, we envisi...
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Bovine viral diarrhea virus (BVDV), the causative agent of bovine viral diarrhea/mucosal disease (BVD/MD), is an important pathogen of cattle and other wild animals throughout the world. BVDV infection typically leads to an impaired immune response in cattle. In the present study, we investigated the effect of Forsythoside A (FTA) on BVDV infection of bovine peripheral blood mononuclear cells (...
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ژورنال
عنوان ژورنال: Immunity
سال: 2001
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(01)00248-5